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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
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Cytomics
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Pi [nucleoplasm]
Stable Identifier
R-ALL-113550
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
Orthophosphate, hydrogenphosphate, Phosphate, Inorganic Phosphate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Nuclear Envelope Breakdown (Bos taurus)
Depolymerization of the Nuclear Lamina (Bos taurus)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)
Pi [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)
Pi [nucleoplasm]
G1/S Transition (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
p-MCM2-7 [nucleoplasm] (Bos taurus)
Pi [nucleoplasm]
Cyclin E associated events during G1/S transition (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
Pi [nucleoplasm]
E2F mediated regulation of DNA replication (Bos taurus)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Bos taurus)
PP2A mediated localization of RB1 protein in chromatin (Bos taurus)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)
Pi [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
Pi [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
Myosin phosphatase dephosphorylates PLK1 (Bos taurus)
Pi [nucleoplasm]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
Pi [nucleoplasm]
Chromosome Maintenance (Bos taurus)
Telomere Maintenance (Bos taurus)
Extension of Telomeres (Bos taurus)
Telomere C-strand (Lagging Strand) Synthesis (Bos taurus)
Polymerase switching on the C-strand of the telomere (Bos taurus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
Pi [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Bos taurus)
Pi [nucleoplasm]
Telomere Extension By Telomerase (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
Pi [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
Pi [nucleoplasm]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
Pi [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
Pi [nucleoplasm]
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
Pi [nucleoplasm]
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
Pi [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Bos taurus)
Pi [nucleoplasm]
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
Pi [nucleoplasm]
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
Pi [nucleoplasm]
DNA Replication (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
Mcm2-7 is phosphorylated by DDK (Bos taurus)
p-MCM2-7 [nucleoplasm] (Bos taurus)
Pi [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
PI5P Regulates TP53 Acetylation (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
Pi [nucleoplasm]
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)
Pi [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
Pi [nucleoplasm]
Transcriptional regulation by RUNX1 (Bos taurus)
Regulation of RUNX1 Expression and Activity (Bos taurus)
PTPN11 dephosphorylates RUNX1 (Bos taurus)
Pi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Bos taurus)
RNA Polymerase II Promoter Opening: First Transition (Bos taurus)
Pi [nucleoplasm]
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon gamma signaling (Bos taurus)
Regulation of IFNG signaling (Bos taurus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)
Pi [nucleoplasm]
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs in the nucleus (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
Pi [nucleoplasm]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT16 hydrolyses IDP to IMP (Bos taurus)
Pi [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
Pi [nucleoplasm]
Metabolism of RNA (Bos taurus)
Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
Transport of Mature Transcript to Cytoplasm (Bos taurus)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Bos taurus)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
Pi [nucleoplasm]
mRNA Splicing (Bos taurus)
mRNA Splicing - Major Pathway (Bos taurus)
Formation of the Spliceosomal Bact complex (Bos taurus)
Pi [nucleoplasm]
Formation of the Spliceosomal C* complex (Bos taurus)
Pi [nucleoplasm]
mRNA Capping (Bos taurus)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)
Pi [nucleoplasm]
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [nucleoplasm]
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [nucleoplasm]
MAPK6/MAPK4 signaling (Bos taurus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)
Pi [nucleoplasm]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Estrogen-dependent gene expression (Bos taurus)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Bos taurus)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
ERK/MAPK targets (Bos taurus)
ERKs are inactivated (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Bos taurus)
Pi [nucleoplasm]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
Pi [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Prophase (Caenorhabditis elegans)
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Depolymerization of the Nuclear Lamina (Caenorhabditis elegans)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)
Pi [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)
Pi [nucleoplasm]
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)
Pi [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)
Pi [nucleoplasm]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)
Pi [nucleoplasm]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
Pi [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Formation of Incision Complex in GG-NER (Caenorhabditis elegans)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
Pi [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
Pi [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
Pi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Caenorhabditis elegans)
RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)
Pi [nucleoplasm]
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Innate Immune System (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs in the nucleus (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
Pi [nucleoplasm]
Metabolism of RNA (Caenorhabditis elegans)
Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
Transport of Mature Transcript to Cytoplasm (Caenorhabditis elegans)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Caenorhabditis elegans)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)
Pi [nucleoplasm]
mRNA Splicing (Caenorhabditis elegans)
mRNA Splicing - Major Pathway (Caenorhabditis elegans)
Formation of the Spliceosomal C* complex (Caenorhabditis elegans)
Pi [nucleoplasm]
mRNA Capping (Caenorhabditis elegans)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)
Pi [nucleoplasm]
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK6/MAPK4 signaling (Caenorhabditis elegans)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Caenorhabditis elegans)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
ERK/MAPK targets (Caenorhabditis elegans)
ERKs are inactivated (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
Pi [nucleoplasm]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
Pi [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Prophase (Canis familiaris)
Nuclear Envelope Breakdown (Canis familiaris)
Depolymerization of the Nuclear Lamina (Canis familiaris)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)
Pi [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)
Pi [nucleoplasm]
G1/S Transition (Canis familiaris)
Cyclin E associated events during G1/S transition (Canis familiaris)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
Pi [nucleoplasm]
E2F mediated regulation of DNA replication (Canis familiaris)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Canis familiaris)
PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)
Pi [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
Pi [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
Myosin phosphatase dephosphorylates PLK1 (Canis familiaris)
Pi [nucleoplasm]
S Phase (Canis familiaris)
Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)
Pi [nucleoplasm]
Chromosome Maintenance (Canis familiaris)
Telomere Maintenance (Canis familiaris)
Extension of Telomeres (Canis familiaris)
Telomere C-strand (Lagging Strand) Synthesis (Canis familiaris)
Polymerase switching on the C-strand of the telomere (Canis familiaris)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
Pi [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
Pi [nucleoplasm]
Telomere Extension By Telomerase (Canis familiaris)
PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)
Pi [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
Pi [nucleoplasm]
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Resolution of Abasic Sites (AP sites) (Canis familiaris)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Canis familiaris)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
Pi [nucleoplasm]
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
Pi [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Canis familiaris)
Pi [nucleoplasm]
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
Pi [nucleoplasm]
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
Formation of Incision Complex in GG-NER (Canis familiaris)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
Pi [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Acetylation (Canis familiaris)
PI5P Regulates TP53 Acetylation (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)
Pi [nucleoplasm]
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)
Pi [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
Pi [nucleoplasm]
Transcriptional regulation by RUNX1 (Canis familiaris)
Regulation of RUNX1 Expression and Activity (Canis familiaris)
PTPN11 dephosphorylates RUNX1 (Canis familiaris)
Pi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Canis familiaris)
RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)
Pi [nucleoplasm]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon gamma signaling (Canis familiaris)
Regulation of IFNG signaling (Canis familiaris)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)
Pi [nucleoplasm]
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs in the nucleus (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)
Pi [nucleoplasm]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT16 hydrolyses IDP to IMP (Canis familiaris)
Pi [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
Pi [nucleoplasm]
Metabolism of RNA (Canis familiaris)
Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
mRNA Splicing (Canis familiaris)
mRNA Splicing - Major Pathway (Canis familiaris)
Formation of the Spliceosomal B complex (Canis familiaris)
Pi [nucleoplasm]
Formation of the Spliceosomal C* complex (Canis familiaris)
Pi [nucleoplasm]
mRNA Capping (Canis familiaris)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Canis familiaris)
Pi [nucleoplasm]
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
Pi [nucleoplasm]
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
Pi [nucleoplasm]
MAPK6/MAPK4 signaling (Canis familiaris)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
Pi [nucleoplasm]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
Pi [nucleoplasm]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
Mitotic G1 phase and G1/S transition (Danio rerio)
G1 Phase (Danio rerio)
Cyclin D associated events in G1 (Danio rerio)
Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)
Pi [nucleoplasm]
G1/S Transition (Danio rerio)
E2F mediated regulation of DNA replication (Danio rerio)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Danio rerio)
PP2A mediated localization of RB1 protein in chromatin (Danio rerio)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
Cyclin A/B1/B2 associated events during G2/M transition (Danio rerio)
PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Danio rerio)
Myosin phosphatase dephosphorylates PLK1 (Danio rerio)
Pi [nucleoplasm]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)
Pi [nucleoplasm]
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Danio rerio)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
Pi [nucleoplasm]
DNA Double-Strand Break Repair (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
Processing of DNA double-strand break ends (Danio rerio)
PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
Pi [nucleoplasm]
Nucleotide Excision Repair (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
Formation of Incision Complex in GG-NER (Danio rerio)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
Dual incision in TC-NER (Danio rerio)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
Pi [nucleoplasm]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Activity through Acetylation (Danio rerio)
PI5P Regulates TP53 Acetylation (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
Pi [nucleoplasm]
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Interferon Signaling (Danio rerio)
Interferon gamma signaling (Danio rerio)
Regulation of IFNG signaling (Danio rerio)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)
Pi [nucleoplasm]
Signaling by Interleukins (Danio rerio)
Interleukin-17 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs in the nucleus (Danio rerio)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
Pi [nucleoplasm]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT16 hydrolyses IDP to IMP (Danio rerio)
Pi [nucleoplasm]
NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
Pi [nucleoplasm]
Metabolism of RNA (Danio rerio)
mRNA Capping (Danio rerio)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)
Pi [nucleoplasm]
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
Pi [nucleoplasm]
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
Pi [nucleoplasm]
MAPK6/MAPK4 signaling (Danio rerio)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Nuclear Events (kinase and transcription factor activation) (Danio rerio)
ERK/MAPK targets (Danio rerio)
ERKs are inactivated (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Danio rerio)
Pi [nucleoplasm]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Prophase (Dictyostelium discoideum)
Nuclear Envelope Breakdown (Dictyostelium discoideum)
Depolymerization of the Nuclear Lamina (Dictyostelium discoideum)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
G1 Phase (Dictyostelium discoideum)
Cyclin D associated events in G1 (Dictyostelium discoideum)
Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)
Pi [nucleoplasm]
G1/S Transition (Dictyostelium discoideum)
E2F mediated regulation of DNA replication (Dictyostelium discoideum)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Dictyostelium discoideum)
PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)
Pi [nucleoplasm]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Dictyostelium discoideum)
Pi [nucleoplasm]
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Dictyostelium discoideum)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)
Pi [nucleoplasm]
DNA Double-Strand Break Repair (Dictyostelium discoideum)
DNA Double Strand Break Response (Dictyostelium discoideum)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Dictyostelium discoideum)
PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)
Pi [nucleoplasm]
Nucleotide Excision Repair (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
Formation of Incision Complex in GG-NER (Dictyostelium discoideum)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Dual incision in TC-NER (Dictyostelium discoideum)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
Pi [nucleoplasm]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Dictyostelium discoideum)
RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)
Pi [nucleoplasm]
Immune System (Dictyostelium discoideum)
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-17 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Innate Immune System (Dictyostelium discoideum)
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Metabolism of RNA (Dictyostelium discoideum)
mRNA Capping (Dictyostelium discoideum)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)
Pi [nucleoplasm]
Signal Transduction (Dictyostelium discoideum)
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Pi [nucleoplasm]
RAF/MAP kinase cascade (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by NTRKs (Dictyostelium discoideum)
Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
Nuclear Events (kinase and transcription factor activation) (Dictyostelium discoideum)
ERK/MAPK targets (Dictyostelium discoideum)
ERKs are inactivated (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
Pi [nucleoplasm]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Prophase (Drosophila melanogaster)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Depolymerization of the Nuclear Lamina (Drosophila melanogaster)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)
Pi [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)
Pi [nucleoplasm]
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)
Pi [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)
Pi [nucleoplasm]
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
Pi [nucleoplasm]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
Pi [nucleoplasm]
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
DNA Double Strand Break Response (Drosophila melanogaster)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)
Pi [nucleoplasm]
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)
Pi [nucleoplasm]
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Formation of Incision Complex in GG-NER (Drosophila melanogaster)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
Pi [nucleoplasm]
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)
Pi [nucleoplasm]
PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)
Pi [nucleoplasm]
JAK/STAT pathway (Drosophila melanogaster)
Dephosphorylation by PTP61F phosphatases (Drosophila melanogaster)
STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol (Drosophila melanogaster)
Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)
Pi [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
PI5P Regulates TP53 Acetylation (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
Pi [nucleoplasm]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
Pi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Drosophila melanogaster)
RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)
Pi [nucleoplasm]
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Interferon gamma signaling (Drosophila melanogaster)
Regulation of IFNG signaling (Drosophila melanogaster)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)
Pi [nucleoplasm]
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs in the nucleus (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
Pi [nucleoplasm]
Metabolism of RNA (Drosophila melanogaster)
Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Drosophila melanogaster)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)
Pi [nucleoplasm]
mRNA Splicing (Drosophila melanogaster)
mRNA Splicing - Major Pathway (Drosophila melanogaster)
Formation of the Spliceosomal C* complex (Drosophila melanogaster)
Pi [nucleoplasm]
mRNA Capping (Drosophila melanogaster)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)
Pi [nucleoplasm]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Estrogen-dependent gene expression (Drosophila melanogaster)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
Pi [nucleoplasm]
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
Pi [nucleoplasm]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Prophase (Gallus gallus)
Nuclear Envelope Breakdown (Gallus gallus)
Depolymerization of the Nuclear Lamina (Gallus gallus)
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Gallus gallus)
G1/S Transition (Gallus gallus)
Activation of the pre-replicative complex (Gallus gallus)
Mcm2-7 is phosphorylated by DDK (Gallus gallus)
p-MCM2-7 [nucleoplasm] (Gallus gallus)
Pi [nucleoplasm]
Cyclin E associated events during G1/S transition (Gallus gallus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
Cyclin A/B1/B2 associated events during G2/M transition (Gallus gallus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Gallus gallus)
Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)
Pi [nucleoplasm]
S Phase (Gallus gallus)
Cyclin A:Cdk2-associated events at S phase entry (Gallus gallus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)
Pi [nucleoplasm]
Chromosome Maintenance (Gallus gallus)
Telomere Maintenance (Gallus gallus)
Extension of Telomeres (Gallus gallus)
Telomere C-strand (Lagging Strand) Synthesis (Gallus gallus)
Polymerase switching on the C-strand of the telomere (Gallus gallus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)
Pi [nucleoplasm]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
ATP hydrolysis by HSP90 (Gallus gallus)
Pi [nucleoplasm]
DNA Repair (Gallus gallus)
DNA Double-Strand Break Repair (Gallus gallus)
DNA Double Strand Break Response (Gallus gallus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Gallus gallus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)
Pi [nucleoplasm]
Homology Directed Repair (Gallus gallus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
Processing of DNA double-strand break ends (Gallus gallus)
PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)
Pi [nucleoplasm]
Nucleotide Excision Repair (Gallus gallus)
Global Genome Nucleotide Excision Repair (GG-NER) (Gallus gallus)
Formation of Incision Complex in GG-NER (Gallus gallus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
Dual incision in TC-NER (Gallus gallus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
Pi [nucleoplasm]
DNA Replication (Gallus gallus)
DNA Replication Pre-Initiation (Gallus gallus)
Activation of the pre-replicative complex (Gallus gallus)
Mcm2-7 is phosphorylated by DDK (Gallus gallus)
p-MCM2-7 [nucleoplasm] (Gallus gallus)
Pi [nucleoplasm]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX1 (Gallus gallus)
Regulation of RUNX1 Expression and Activity (Gallus gallus)
PTPN11 dephosphorylates RUNX1 (Gallus gallus)
Pi [nucleoplasm]
RNA Polymerase II Transcription Initiation And Promoter Clearance (Gallus gallus)
RNA Polymerase II Promoter Opening: First Transition (Gallus gallus)
Pi [nucleoplasm]
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
Regulation of IFNG signaling (Gallus gallus)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)
Pi [nucleoplasm]
Signaling by Interleukins (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Metabolism of RNA (Gallus gallus)
mRNA Capping (Gallus gallus)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)
Pi [nucleoplasm]
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF-independent MAPK1/3 activation (Gallus gallus)
Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
Pi [nucleoplasm]
RAF/MAP kinase cascade (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
Pi [nucleoplasm]
MAPK6/MAPK4 signaling (Gallus gallus)
CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)
Pi [nucleoplasm]
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Estrogen-dependent gene expression (Gallus gallus)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Gallus gallus)
Pi [nucleoplasm]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Nuclear Events (kinase and transcription factor activation) (Gallus gallus)
ERK/MAPK targets (Gallus gallus)
ERKs are inactivated (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
Pi [nucleoplasm]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerization of the Nuclear Lamina (Homo sapiens)
CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)
Pi [nucleoplasm]
LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)
Pi [nucleoplasm]
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
Pi [nucleoplasm]
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
Pi [nucleoplasm]
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
Pi [nucleoplasm]
Cyclin E associated events during G1/S transition (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
Pi [nucleoplasm]
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)
Pi [nucleoplasm]
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
Pi [nucleoplasm]
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)
Pi [nucleoplasm]
PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)
Pi [nucleoplasm]
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
Pi [nucleoplasm]
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
Pi [nucleoplasm]
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
Pi [nucleoplasm]
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Pi [nucleoplasm]
Telomere Extension By Telomerase (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Pi [nucleoplasm]
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Pi [nucleoplasm]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)
Pi [nucleoplasm]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
Pi [nucleoplasm]
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
Pi [nucleoplasm]
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
Pi [nucleoplasm]
PPP5C dephosphorylates TP53BP1 (Homo sapiens)
Pi [nucleoplasm]
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
Pi [nucleoplasm]
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
Pi [nucleoplasm]
Processing of DNA double-strand break ends (Homo sapiens)
PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)
Pi [nucleoplasm]
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
Pi [nucleoplasm]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
Pi [nucleoplasm]
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)