Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

Stable Identifier
R-HSA-8952137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
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Phospholipid phosphatase 6 (PLPP6) dephosphorylates presqualene diphosphate (PSQPP) to presqualene monophosphate (PSMP). It may be indirectly involved in innate immunity, as PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. PLPP6 displays diphosphate phosphatase activity with a substrate preference PSDP > FDP > phosphatidic acid.

Literature References
PubMed ID Title Journal Year
16464866 Identification and functional characterization of a presqualene diphosphate phosphatase

Arita, M, Morris, AJ, Levy, BD, Fukunaga, K, Pfeffer, M, Takahashi, M

J. Biol. Chem. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hydrolase activity of PLPP6 [plasma membrane]

Physical Entity
PLPP6 [plasma membrane] (Homo sapiens)
Activity
hydrolase activity (GO:0016787)
Orthologous Events
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)
Cross References
Rhea
Authored
Jupe, S  (2016-12-13)
Reviewed
Levy, BD  (2017-01-23)
Created
Jupe, S  (2016-12-13)
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