Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

Stable Identifier
R-HSA-8952137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipid phosphatase 6 (PLPP6) dephosphorylates presqualene diphosphate (PSQPP) to presqualene monophosphate (PSMP). It may be indirectly involved in innate immunity, as PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. PLPP6 displays diphosphate phosphatase activity with a substrate preference PSDP > FDP > phosphatidic acid.

Literature References
PubMed ID Title Journal Year
16464866 Identification and functional characterization of a presqualene diphosphate phosphatase

Fukunaga, K, Arita, M, Takahashi, M, Morris, AJ, Pfeffer, M, Levy, BD

J. Biol. Chem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity of PLPP6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created