Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

Stable Identifier
R-HSA-8952137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
presqualene diphosphate + H2O => presqualene phosphate + phosphate + H(+)
ReviewStatus
5/5
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Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
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Phospholipid phosphatase 6 (PLPP6) dephosphorylates presqualene diphosphate (PSDP) to presqualene monophosphate (PSMP). It may be indirectly involved in innate immunity, as PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. PLPP6 displays diphosphate phosphatase activity with a substrate preference PSDP > FDP > phosphatidic acid (Fukunaga et al. 2006).
Literature References
PubMed ID Title Journal Year
16464866 Identification and functional characterization of a presqualene diphosphate phosphatase

Fukunaga, K, Arita, M, Takahashi, M, Morris, AJ, Pfeffer, M, Levy, BD

J. Biol. Chem. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hydrolase activity of PLPP6 [plasma membrane]

Physical Entity
PLPP6 [plasma membrane] (Homo sapiens)
Activity
hydrolase activity (GO:0016787)
Orthologous Events
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)
Cross References
RHEA
Authored
Jupe, S  (2016-12-13)
Reviewed
Levy, BD  (2017-01-23)
Hill, DP  (2025-05-30)
Created
Jupe, S  (2016-12-13)
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