Reactome | ABCC4 transports TPMP substrates from cytosol to extracellular region

ABCC4 transports TPMP substrates from cytosol to extracellular region

Stable Identifier

R-HSA-9750546

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

ABCC4 transports thiopurine monophosphates from cytosol to extracellular region

ReviewStatus

5/5

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ABCC4 transports TPMP substrates from cytosol to extracellular region

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ABCC4 is a multidrug resistance protein (MRP4) which can transport a wide range of organic anions but especially nucleotides and nucleotide analogues. When overexpressed, ABCC4 can lower the intracellular concentration of nucleoside/nucleotide analogues such as 6-mercaptopurine (6MP), after its conversion into its respective nucleotides (Wielinga et al. 2002, Ritter et al. 2005, Peng et al. 2008). This may lead to an impaired ability of 6MP to inhibit cell proliferation.

Literature References

PubMed ID	Title	Journal	Year
17996297	Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine Fu, L, Damaraju, VL, Chen, ZS, Shi, Z, Cass, CE, Wu, HC, Peng, XX, Zhou, Y, Tiwari, A, Kruh, GD, Huang, XC	Leuk Res	2008
15747503	Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5) Kroemer, HK, Köck, K, Meyer zu Schwabedissen, H, Ritter, CA, Jedlitschky, G, Grube, M	Drug Metab Rev	2005
12435799	Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells Borst, P, Challa, EE, van Deemter, L, De Abreu, RA, Schuetz, JD, Wielinga, PR, Beijnen, JH, de Haas, M, Wijnholds, J, van der Heijden, I, Groeneveld, E, Brouwer, C, Mol, C, Kuil, AJ, Reid, G	Mol Pharmacol	2002