(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

Stable Identifier
R-HSA-74376
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uridine or deoxyuridine with orthophosphate to yield uracil and ribose 1-phosphate or deoxyribose 1-phosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References
PubMed ID Title Journal Year
7488099 Cloning and expression of human uridine phosphorylase

Uchida, T, Watanabe, SI

Biochem Biophys Res Commun 1995
19291308 Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

Fabbiani, M, Roosild, TP, Pizzorno, G, Castronovo, S

BMC Struct Biol 2009
12849978 Identification of a novel human uridine phosphorylase

Johansson, M

Biochem Biophys Res Commun 2003
Participants
Participates
Catalyst Activity

uridine phosphorylase activity of UPP1, UPP2 [cytosol]

Orthologous Events
Created
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