Reactome | (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

Stable Identifier

R-HSA-74376

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

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Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uridine or deoxyuridine with orthophosphate to yield uracil and ribose 1-phosphate or deoxyribose 1-phosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
7488099	Cloning and expression of human uridine phosphorylase Watanabe, SI, Uchida, T	Biochem Biophys Res Commun	1995
19291308	Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy Roosild, TP, Castronovo, S, Fabbiani, M, Pizzorno, G	BMC Struct Biol	2009
12849978	Identification of a novel human uridine phosphorylase Johansson, M	Biochem Biophys Res Commun	2003