Reactome | (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

Stable Identifier

R-HSA-74376

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

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Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uridine or deoxyuridine with orthophosphate to yield uracil and ribose 1-phosphate or deoxyribose 1-phosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
7488099	Cloning and expression of human uridine phosphorylase Uchida, T, Watanabe, SI	Biochem Biophys Res Commun	1995
19291308	Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy Fabbiani, M, Roosild, TP, Pizzorno, G, Castronovo, S	BMC Struct Biol	2009
12849978	Identification of a novel human uridine phosphorylase Johansson, M	Biochem Biophys Res Commun	2003