Reactome | ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3

ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3

Stable Identifier

R-HSA-9753283

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3

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Glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) can also be secreted into blood via the ATP-binding cassette sub-family C member 3 and 4 transporters (ABCC3 and ABCC4), both found at the basolateral surface of hepatocytes (Giacomini et al. 2010, review McGill & Jaeschke 2013, Koenderink et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
32472168	Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates Koenderink, JB, van den Heuvel, JJMW, Bilos, A, Vredenburg, G, Vermeulen, NPE, Russel, FGM	Arch Toxicol	2020
20190787	Membrane transporters in drug development Giacomini, KM, Huang, SM, Tweedie, DJ, Benet, LZ, Brouwer, KL, Chu, X, Dahlin, A, Evers, R, Fischer, V, Hillgren, KM, Hoffmaster, KA, Ishikawa, T, Keppler, D, Kim, RB, Lee, CA, Niemi, M, Polli, JW, Sugiyama, Y, Swaan, PW, Ware, JA, Wright, SH, Yee, SW, Zamek-Gliszczynski, MJ, Zhang, L	Nat Rev Drug Discov	2010