glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic glutamine synthetase (glutamate-ammonia ligase - GLUL) catalyzes the reaction of glutamate, ammonia, and ATP to form glutamine, ADP, and orthophosphate. The enzyme is a decamer (Krajewski et al. 2008). Mutations in the gene encoding GLUL cause glutamine deficiency in vivo (Haberle et al. 2005).

Literature References
PubMed ID Title Journal Year
18005987 Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design

Holmberg-Schiavone, L, Jones, TA, Mowbray, SL, Collins, R, Krajewski, WW, Karlberg, T

J Mol Biol 2008
16267323 Congenital glutamine deficiency with glutamine synthetase mutations

Gelot, A, Häussinger, D, Toutain, A, Häberle, J, Suc, AL, Hohne, W, Schliess, F, Schmidt, E, Rutsch, F, Gorg, B, Koch, HG, Benoist, JF

N Engl J Med 2005
Catalyst Activity

glutamate-ammonia ligase activity of GLUL decamer [cytosol]

Orthologous Events
Cross References
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