Reactome | glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

Stable Identifier

R-HSA-70606

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate

ReviewStatus

5/5

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glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

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Cytosolic glutamine synthetase (glutamate-ammonia ligase - GLUL) catalyzes the reaction of glutamate, ammonia, and ATP to form glutamine, ADP, and orthophosphate. The enzyme is a decamer (Krajewski et al. 2008). Mutations in the gene encoding GLUL cause glutamine deficiency in vivo (Haberle et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
18005987	Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design Krajewski, WW, Collins, R, Holmberg-Schiavone, L, Jones, TA, Karlberg, T, Mowbray, SL	J Mol Biol	2008
16267323	Congenital glutamine deficiency with glutamine synthetase mutations Häberle, J, Gorg, B, Rutsch, F, Schmidt, E, Toutain, A, Benoist, JF, Gelot, A, Suc, AL, Hohne, W, Schliess, F, Häussinger, D, Koch, HG	N Engl J Med	2005