Cytosolic glutamine synthetase (glutamate-ammonia ligase - GLUL) catalyzes the reaction of glutamate, ammonia, and ATP to form glutamine, ADP, and orthophosphate. The enzyme is a decamer (Krajewski et al. 2008). Mutations in the gene encoding GLUL cause glutamine deficiency in vivo (Haberle et al. 2005).
Holmberg-Schiavone, L, Jones, TA, Mowbray, SL, Collins, R, Krajewski, WW, Karlberg, T
Gelot, A, Häussinger, D, Toutain, A, Häberle, J, Suc, AL, Hohne, W, Schliess, F, Schmidt, E, Rutsch, F, Gorg, B, Koch, HG, Benoist, JF
glutamate-ammonia ligase activity of GLUL decamer [cytosol]
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