Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

Stable Identifier
R-HSA-416546
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
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Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.
Literature References
PubMed ID Title Journal Year
16702230 Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity

Katoh, H, Oinuma, I, Negishi, M

J Cell Biol 2006
16799460 Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse

Kaibuchi, K, Katoh, H, Oinuma, I, Negishi, M, Ito, Y

EMBO Rep 2006
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Output
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as an event of
Catalyst Activity

GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]

Physical Entity
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-30)
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