Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

Stable Identifier
R-HSA-416546
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.

Literature References
PubMed ID Title Journal Year
16799460 Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse

Ito, Y, Oinuma, I, Katoh, H, Kaibuchi, K, Negishi, M

EMBO Rep 2006
16702230 Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity

Oinuma, I, Katoh, H, Negishi, M

J Cell Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created