PTPN7 dephosphorylates p-T,Y-MAPKs

Stable Identifier
R-HSA-9635739
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PTPN7 dephosphorylates ERKs
ReviewStatus
5/5
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PTPN7 dephosphorylates p-T,Y-MAPKs
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Protein tyrosine phosphatase PTPN7 (also known as HePTP) dephosphorylates tyrosine residues of MAPK1 (ERK2) (Saxena et al. 1999, Pettiford and Herbst 2000) and MAPK3 (ERK1) (Saxena et al. 1999), leading to reduction in their catalytic activity.

Literature References
PubMed ID Title Journal Year
10702794 The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP

Pettiford, SM, Herbst, R

Oncogene 2000
10206983 Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)

Brockdorff, J, Williams, S, Mustelin, T, Saxena, M, Gilman, J

J. Biol. Chem. 1999
Participants
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Output
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as an event of
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of PTPN7:p-T,Y-MAPK dimers [cytosol]

Physical Entity
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Orthologous Events
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Caenorhabditis elegans)
PTPN7 dephosphorylates p-T,Y-MAPKs (Canis familiaris)
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)
PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2019-09-23)
Rothfels, K  (2019-10-28)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Orlic-Milacic, M  (2019-02-08)
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