PTPN7 dephosphorylates p-T,Y-MAPKs

Stable Identifier
R-HSA-9635739
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PTPN7 dephosphorylates ERKs
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Protein tyrosine phosphatase PTPN7 (also known as HePTP) dephosphorylates tyrosine residues of MAPK1 (ERK2) (Saxena et al. 1999, Pettiford and Herbst 2000) and MAPK3 (ERK1) (Saxena et al. 1999), leading to reduction in their catalytic activity.

Literature References
PubMed ID Title Journal Year
10206983 Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)

Saxena, M, Williams, S, Brockdorff, J, Gilman, J, Mustelin, T

J. Biol. Chem. 1999
10702794 The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP

Pettiford, SM, Herbst, R

Oncogene 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of PTPN7:p-T,Y-MAPK dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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