ARHGAP35 stimulates RHOA GTPase activity

Stable Identifier
R-HSA-8849082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ARHGAP35 stimulates RHOA GTPase activity
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ARHGAP35 (p190 Rho GAP), phosphorylated on tyrosine residue Y1105 by PTK6 (BRK), activates RHOA GTPase activity, resulting in RHOA inactivation (Shen et al. 2008).

Literature References
PubMed ID Title Journal Year
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH

Cancer Res. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GTPase activity of p-Y1105-ARHGAP35:RHOA:GTP [cytosol]
Physical Entity
p-Y1105-ARHGAP35:RHOA:GTP [cytosol]
Activity
GTPase activity (0003924)
Orthologous Events
ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)
ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)
ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)
ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)
ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)
ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)
ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)
ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)
ARHGAP35 stimulates RHOA GTPase activity (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)