ARHGAP35 stimulates RHOA GTPase activity

Stable Identifier
R-HSA-8849082
Type
Reaction
Species
Homo sapiens
Compartment
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ARHGAP35 (p190 Rho GAP), phosphorylated on tyrosine residue Y1105 by PTK6 (BRK), activates RHOA GTPase activity, resulting in RHOA inactivation (Shen et al. 2008).

Literature References
PubMed ID Title Journal Year
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Kuo, ML, Li, FY, Settleman, J, Shen, CH, Chen, HY, Chang, CC, Chen, RH, Lin, MS

Cancer Res. 2008
Participants
Participates
Catalyst Activity

GTPase activity of p-Y1105-ARHGAP35:RHOA:GTP [cytosol]

Orthologous Events
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