N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

Stable Identifier
R-HSA-8942575
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

N-Acetylaspartylglutamate (NAAG) is found at high concentrations in the vertebrate nervous system. It is an agonist of group II metabotropic glutamate receptors. A number of other functions have been proposed for NAAG, including a role as a non-excitotoxic transport form of glutamate and a molecular water pump (Lodder-Gadaczek et al. 2011, Neale et al. 2011). NAAG is synthesized by N-acetylaspartylglutamate synthase A (RIMKLA, NAAG synthetase A) and Beta-citrylglutamate synthase B (RIMKLB, NAAG synthetase B), which more efficiently catalyzes the synthesis of beta-citryl-L-glutamate (Collard et al. 2010, Lodder-Gadaczek et al. 2011).

Literature References
PubMed ID Title Journal Year
20657015 Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase

Collard, F, Stroobant, V, Lamosa, P, Kapanda, CN, Lambert, DM, Muccioli, GG, Poupaert, JH, Opperdoes, F, Van Schaftingen, E

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acetyl-L-aspartate-L-glutamate ligase activity of RIMKLA, RIMKLB [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created