Reactome | N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

Stable Identifier

R-HSA-8942575

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate

ReviewStatus

5/5

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N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

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N-Acetylaspartylglutamate (NAAG) is found at high concentrations in the vertebrate nervous system. It is an agonist of group II metabotropic glutamate receptors. A number of other functions have been proposed for NAAG, including a role as a non-excitotoxic transport form of glutamate and a molecular water pump (Lodder-Gadaczek et al. 2011, Neale et al. 2011). NAAG is synthesized by N-acetylaspartylglutamate synthase A (RIMKLA, NAAG synthetase A) and Beta-citrylglutamate synthase B (RIMKLB, NAAG synthetase B), which more efficiently catalyzes the synthesis of beta-citryl-L-glutamate (Collard et al. 2010, Lodder-Gadaczek et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20657015	Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase Lambert, DM, Stroobant, V, Kapanda, CN, Muccioli, GG, Opperdoes, F, Van Schaftingen, E, Lamosa, P, Collard, F, Poupaert, JH	J. Biol. Chem.	2010