PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin

Stable Identifier
R-HSA-9865238
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Interaction between integrin alpha5 (ITGA5) and fibronectin causes ITGA5 to recruit p-S715-PDE4D5, which then binds the PPP2R2A (B55alpha) subunit of the protein phosphatase PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) (inferred from bovine homologs). The PPP2CA subunit of PP2A subsequently binds PPP2R2A and dephosphorylates serine-715 of PDE4D5 (inferred from bovine homologs). Dephosphorylation of PDE4D5 is thought to increase its phosphodiesterase activity, which causes hydrolysis of cAMP. Cyclic AMP is anti-inflammatory due to its enhancement of PKA activity (Funk et al. 2010), therefore PDE4D5 appears to be pro-inflammatory.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane]

Physical Entity
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Inferred From
PP2A dephosphorylates p-S585-PDE4D in p-S585-PDE4D:integrin alpha5:beta1:fibronectin (Bos taurus)
Authored
May, B  (2024-03-09)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-09)
Cite Us!