Reactome | MVD decarboxylates MVA5PP to IPPP

MVD decarboxylates MVA5PP to IPPP

Stable Identifier

R-HSA-191414

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mevalonate-5-pyrophosphate is decarboxylated

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        MVD decarboxylates MVA5PP to IPPP (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mevalonate pyrophosphate decarboxylase (MPD) decarboxylates mevalonate-5-pyrophosphate (MVA5PP) into isopentenyl pyrophosphate (IPPP) while hydrolysing ATP to ADP and orthophosphate (Toth & Huwyler 1996).

Literature References

PubMed ID	Title	Journal	Year
8626466	Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase Huwyler, L, Toth, MJ	J Biol Chem	1996