Reactome | MVD decarboxylates MVA5PP to IPPP

MVD decarboxylates MVA5PP to IPPP

Stable Identifier

R-HSA-191414

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mevalonate-5-pyrophosphate is decarboxylated

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        MVD decarboxylates MVA5PP to IPPP (Homo sapiens)

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Mevalonate pyrophosphate decarboxylase (MPD) decarboxylates mevalonate-5-pyrophosphate (MVA5PP) into isopentenyl pyrophosphate (IPPP) while hydrolysing ATP to ADP and orthophosphate (Toth & Huwyler 1996).

Literature References

PubMed ID	Title	Journal	Year
8626466	Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase Huwyler, L, Toth, MJ	J Biol Chem	1996