RHOT1 hydrolyzes GTP

Stable Identifier
R-HSA-9018814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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RHOT1 hydrolyzes GTP
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RHOT1 (Miro1) possesses a high intrinsic GTPase activity and does not require a GTPase activator protein (GAP) to hydrolyze GTP (Peters et al. 2018).
Literature References
PubMed ID Title Journal Year
30513825 Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism

Peters, DT, Kay, L, Eswaran, J, Lakey, JH, Soundararajan, M

Int J Mol Sci 2018
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Output
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Catalyst Activity

GTPase activity of RHOT1:GTP [mitochondrial outer membrane]

Physical Entity
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
RHOT1 hydrolyzes GTP (Bos taurus)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Canis familiaris)
RHOT1 hydrolyzes GTP (Danio rerio)
RHOT1 hydrolyzes GTP (Drosophila melanogaster)
RHOT1 hydrolyzes GTP (Gallus gallus)
RHOT1 hydrolyzes GTP (Mus musculus)
RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)
RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)
RHOT1 hydrolyzes GTP (Sus scrofa)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Schrader, M  (2021-02-09)
Castro, IG  (2021-02-09)
Created
Orlic-Milacic, M  (2017-09-05)
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