PTP1B dephosphorylates GHR

Stable Identifier
R-HSA-1169192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PTP1B dephosphorylates GHR
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PTP1B induces the dephosphorylation of GHR (Pasquali et al. 2003).
Literature References
PubMed ID Title Journal Year
12907755 Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

Pasquali, C, Curchod, ML, Wälchli, S, Espanel, X, Guerrier, M, Arigoni, F, Strous, G, Hooft van Huijsduijnen, R

Mol Endocrinol 2003
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]

Physical Entity
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTP1B dephosphorylates GHR (Bos taurus)
PTP1B dephosphorylates GHR (Canis familiaris)
PTP1B dephosphorylates GHR (Danio rerio)
PTP1B dephosphorylates GHR (Gallus gallus)
PTP1B dephosphorylates GHR (Mus musculus)
PTP1B dephosphorylates GHR (Rattus norvegicus)
PTP1B dephosphorylates GHR (Sus scrofa)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-13)
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