Exportin complex translocates pre-miRNA to cytosol

Stable Identifier
R-HSA-203906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Exportin complex translocates pre-miRNA to cytosol
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Nuclear Export by Exportin-5. The pre-microRNA is bound by the Exportin-5:RanGTP complex in the nucleus and the complex is translocated through the nuclear pore into the cytoplasm. In the process GTP is hydrolyzed to GDP.
Literature References
PubMed ID Title Journal Year
14631048 Nuclear export of microRNA precursors

Kutay, U, Dahlberg, JE, Lund, E, Calado, A, Güttinger, S

Science 2004
14681208 Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

Macara, IG, Yi, R, Cullen, BR, Qin, Y

Genes Dev 2003
14730017 Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Gorlich, D, Czaplinski, K, Bohnsack, MT

RNA 2004
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Catalyst Activity

RNA transmembrane transporter activity of pre-miRNA:RAN:GTP:Exportin-5 [nucleoplasm]

Physical Entity
pre-miRNA:RAN:GTP:Exportin-5 [nucleoplasm] (Homo sapiens)
Activity
RNA transmembrane transporter activity (GO:0051033)
Authored
Gopinathrao, G  (2007-11-19)
May, B  (2007-11-19)
Reviewed
Hannon, GJ  (2008-02-08)
Karginov, F  (2008-02-08)
Created
Gopinathrao, G  (2007-11-19)
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