Exportin complex translocates pre-miRNA to cytosol

Stable Identifier
R-HSA-203906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Nuclear Export by Exportin-5. The pre-microRNA is bound by the Exportin-5:RanGTP complex in the nucleus and the complex is translocated through the nuclear pore into the cytoplasm. In the process GTP is hydrolyzed to GDP.

Literature References
PubMed ID Title Journal Year
14681208 Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

Yi, R, Qin, Y, Macara, IG, Cullen, BR

Genes Dev 2003
14631048 Nuclear export of microRNA precursors

Lund, E, G├╝ttinger, S, Calado, A, Dahlberg, JE, Kutay, U

Science 2004
14730017 Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Bohnsack, MT, Czaplinski, K, Gorlich, D

RNA 2004
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Catalyst Activity
Title
RNA transmembrane transporter activity of pre-miRNA:RAN:GTP:Exportin-5 [nucleoplasm]
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