Reactome | MAT1A multimers transfer Ado from ATP to L-Met

MAT1A multimers transfer Ado from ATP to L-Met

Stable Identifier

R-HSA-174391

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine, SAM is sythesized from methionine's reaction with ATP

ReviewStatus

5/5

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MAT1A multimers transfer Ado from ATP to L-Met

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S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). MAT1A binds 1 K+ and 2 Mg2+ (or Co2+, not shown here) in tetrameric or dimeric form (Corrales et al. 2002, Mato et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
12163696	Regulation of mammalian liver methionine adenosyltransferase Corrales, FJ, Pérez-Mato, I, Sánchez Del Pino, MM, Ruiz, F, Castro, C, García-Trevijano, ER, Latasa, U, Martinez-Chantar, ML, Martinez-Cruz, A, Avila, MA, Mato, JM	J Nutr	2002
9175157	S-adenosylmethionine synthesis: molecular mechanisms and clinical implications Mato, JM, Alvarez, L, Ortiz, P, Pajares, MA	Pharmacol Ther	1997