Hydrolysis of eEF1A:GTP

Stable Identifier
R-HSA-156923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hydrolysis of eEF1A:GTP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form of eEF1A is released from the ribosome.
This process is illustrated below with: an amino acyl-tRNA with an amino acid,a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA.
Literature References
PubMed ID Title Journal Year
6568109 Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes

Carvalho, JF, Merrick, WC, Carvalho, MD

Arch Biochem Biophys 1984
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Catalyst Activity

GTPase activity of 80S ribosome [cytosol]

Physical Entity
80S ribosome [cytosol] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Inferred From
Hydrolysis of reEF1A:GTP (Oryctolagus cuniculus)
Authored
Gopinathrao, G  (2005-03-17)
Created
Kinzy, TG  (2005-03-17)
Ozturk, S  (2005-03-17)
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