VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol

Stable Identifier
R-HSA-8866542
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
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VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
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Retrotranslocation of the misfolded CFTR likely depends on the ERAD ATPase VCP (reviewed in Vembar and Brodsky, 2008; Pranke and Sermet-Gaudelus, 2014).

Literature References
PubMed ID Title Journal Year
19002207 One step at a time: endoplasmic reticulum-associated degradation

Vembar, SS, Brodsky, JL

Nat. Rev. Mol. Cell Biol. 2008
24685677 Biosynthesis of cystic fibrosis transmembrane conductance regulator

Pranke, IM, Sermet-Gaudelus, I

Int. J. Biochem. Cell Biol. 2014
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Orthologous Events
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)
Authored
Rothfels, K  (2016-04-02)
Reviewed
D'Eustachio, P  (2016-04-23)
Created
Rothfels, K  (2016-04-02)