AMP + H2O => adenosine + orthophosphate [NT5C1B]

Stable Identifier
R-HSA-109415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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AMP + H2O => adenosine + orthophosphate [NT5C1B]
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5'-nucleotidase cytosolic IB catalyzes the hydrolysis of AMP to yield adenosine and orthophosphate. The human enzyme has been identified as the product of a recombinant DNA clone, but its biochemical properties are largely inferred from those of the better studied mouse and rat enzymes (Sala-Newby and Newby 2001; Sala-Newby et al. 2003).

Literature References
PubMed ID Title Journal Year
11690631 Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein

Sala-Newby, GB, Newby, AC

Biochim Biophys Acta 2001
12750059 Metabolic and functional consequences of cytosolic 5'-nucleotidase-IA overexpression in neonatal rat cardiomyocytes

Sala-Newby, GB, Freeman, NV, Curto, MA, Newby, AC

Am J Physiol Heart Circ Physiol 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
5'-nucleotidase activity of NT5C1B [cytosol]
Physical Entity
NT5C1B [cytosol]
Activity
5'-nucleotidase activity (0008253)
This event is regulated
Positively by
Orthologous Events
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Xenopus tropicalis)
Cross References
Rhea
Created
D'Eustachio, P  (2004-01-06)