ABCC2 transports BMG,BDG from cytosol to extracellular region

Stable Identifier
R-HSA-5679041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Canalicular multispecific organic anion transporter 1 (ABCC2 aka multidrug resistance-associated protein 2, MRP2), in addition to transporting many organic anions, mediates the ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into bile. In the reaction annotated here, ABCC2 specifically transports, with high affinity and efficiency, mono- and di-glucuronated bilirubin into bile (Kamisako et al. 1999). Bilirubin, the end product of heme breakdown, is an important constituent of bile and is responsible for its characteristic colour.

Literature References
PubMed ID Title Journal Year
10421658 Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2

Kamisako, T, Leier, I, Cui, Y, K├Ânig, J, Buchholz, U, Hummel-Eisenbeiss, J, Keppler, D

Hepatology 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
bilirubin transmembrane transporter activity of ABCC2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created