ATP13A2 transports cations from cytosol to lysosomal lumen

Stable Identifier
R-HSA-5692480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, lysosomal lumen, lysosomal membrane
ReviewStatus
5/5
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ATP13A2 transports cations from cytosol to lysosomal lumen
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The probable cation-transporting ATPase 13A2 (ATP13A2) is thought to play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (Ramonet et al. 2012). Defects in ATP13A2 can cause Kufor-Rakeb syndrome (KRS; MIM:606693), a juvenile-onset Levodopa-responsive parkinsonism (Lai et al. 2012).
Literature References
PubMed ID Title Journal Year
23196729 Early-onset autosomal-recessive parkinsonian-pyramidal syndrome

Lai, HJ, Lin, CH, Wu, RM

Acta Neurol Taiwan 2012
22186024 PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Ramonet, D, Podhajska, A, Stafa, K, Sonnay, S, Trancikova, A, Tsika, E, Pletnikova, O, Troncoso, JC, Glauser, L, Moore, DJ

Hum. Mol. Genet. 2012
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Catalyst Activity

ATPase-coupled monoatomic cation transmembrane transporter activity of ATP13A2 [lysosomal lumen]

Physical Entity
ATP13A2 [lysosomal lumen] (Homo sapiens)
Activity
ATPase-coupled monoatomic cation transmembrane transporter activity (GO:0019829)
Orthologous Events
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Caenorhabditis elegans)
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
ATP13A2 transports cations from cytosol to lysosomal lumen (Drosophila melanogaster)
ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)
ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)
ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)
ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-12)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-12)
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