Reactome | PANK4 hydrolyzes PPANT to pantetheine

PANK4 hydrolyzes PPANT to pantetheine

Stable Identifier

R-HSA-9837419

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate

ReviewStatus

5/5

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Cytosolic PANK4 hydrolyzes (R)-4'-phosphopantetheine (PPANT) to pantetheine (Huang et al. 2016). This reaction, coupled to the hydrolysis of CoA-SH mediated by NUDT enzymes, could play a role in rapidly reducing cellular CoA levels in response to changes in requirements for energy metabolism (Naquet et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
32234503	Regulation of coenzyme A levels by degradation: the 'Ins and Outs' Naquet, P, Kerr, EW, Vickers, SD, Leonardi, R	Prog Lipid Res	2020
27322068	A family of metal-dependent phosphatases implicated in metabolite damage-control Huang, L, Khusnutdinova, A, Nocek, B, Brown, G, Xu, X, Cui, H, Petit, P, Flick, R, Zallot, R, Balmant, K, Ziemak, MJ, Shanklin, J, de Crecy-Lagard, V, Fiehn, O, Gregory, JF, Joachimiak, A, Savchenko, A, Yakunin, AF, Hanson, AD	Nat Chem Biol	2016