I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Stable Identifier
R-HSA-1855205
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).

Literature References
PubMed ID Title Journal Year
9593664 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Dixon, JE, Maehama, T

J Biol Chem 1998
10866302 Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

Kato, H, Shibata, H, Matsuno, S, Shiiba, K, Han, SY, Kato, S, Ishioka, C, Ishii, S, Kanamaru, R, Suzuki, T

Cancer Res 2000
Participants
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Catalyst Activity

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity of PTEN:Mg2+ [cytosol]

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