I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Stable Identifier
R-HSA-1855205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
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Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).
Literature References
PubMed ID Title Journal Year
9593664 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T, Dixon, JE

J Biol Chem 1998
10866302 Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

Han, SY, Kato, H, Kato, S, Suzuki, T, Shibata, H, Ishii, S, Shiiba, K, Matsuno, S, Kanamaru, R, Ishioka, C

Cancer Res 2000
Participants
Input
Output
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as an event of
Catalyst Activity

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity of PTEN:Mg2+ [cytosol]

Physical Entity
PTEN:Mg2+ [cytosol] (Homo sapiens)
Activity
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity (GO:0051717)
Orthologous Events
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
Williams, MG  (2011-10-28)
Created
Williams, MG  (2011-10-28)
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