Reactome | I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Stable Identifier

R-HSA-1855205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

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Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
9593664	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate Dixon, JE, Maehama, T	J Biol Chem	1998
10866302	Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay Kato, H, Shibata, H, Matsuno, S, Shiiba, K, Han, SY, Kato, S, Ishioka, C, Ishii, S, Kanamaru, R, Suzuki, T	Cancer Res	2000