Reactome | TBC1D15 accelerates GTP hydrolysis by RAB7

TBC1D15 accelerates GTP hydrolysis by RAB7

Stable Identifier

R-HSA-8854329

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TBC1D15 accelerates GTP hydrolysis by RAB7

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The small GTPase Rab7 promotes fusion events between late endosomes and lysosomes. TBC domain family, member 15 (TAB1CD15) is ubiquitously expressed and localized predominantly to the cytosol. TBC1D15 stimulates the intrinsic GTPase activity of Rab7, reducing Rab7 binding to its effector protein RILP, fragmenting the lysosome, and conferring resistance to growth factor withdrawal-induced cell death (Zhang et al. 2005, Peralta et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16055087	TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7 Zhang, XM, Walsh, B, Mitchell, CA, Rowe, T	Biochem. Biophys. Res. Commun.	2005
20363736	Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence Peralta, ER, Martin, BC, Edinger, AL	J. Biol. Chem.	2010