Reactome | HCO3- transport through ion channel

HCO3- transport through ion channel

Stable Identifier

R-HSA-383190

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). CFTR regulates both HCO(3)(-) secretion and HCO(3)(-) salvage in secretory epithelia.

Literature References

PubMed ID	Title	Journal	Year
11562789	Na+:HCO(3-) cotransporters (NBC): cloning and characterization Soleimani, M, Burnham, CE	J Membr Biol	2001
12403779	The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3 Park, M, Ko, SB, Choi, JY, Muallem, G, Thomas, PJ, Pushkin, A, Lee, MS, Kim, JY, Lee, MG, Muallem, S, Kurtz, I	J Biol Chem	2002
1377674	Phosphorylation of the cystic fibrosis transmembrane conductance regulator Picciotto, MR, Cohn, JA, Bertuzzi, G, Greengard, P, Nairn, AC	J Biol Chem	1992