HCO3- transport through ion channel

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). CFTR regulates both HCO(3)(-) secretion and HCO(3)(-) salvage in secretory epithelia.

Literature References
PubMed ID Title Journal Year
11562789 Na+:HCO(3-) cotransporters (NBC): cloning and characterization

Soleimani, M, Burnham, CE

J Membr Biol 2001
12403779 The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3

Choi, JY, Lee, MG, Ko, SB, Muallem, S, Pushkin, A, Thomas, PJ, Lee, MS, Muallem, G, Park, M, Kim, JY, Kurtz, I

J Biol Chem 2002
1377674 Phosphorylation of the cystic fibrosis transmembrane conductance regulator

Picciotto, MR, Bertuzzi, G, Greengard, P, Nairn, AC, Cohn, JA

J Biol Chem 1992
Catalyst Activity

chloride channel regulator activity of CFTR [plasma membrane]

Orthologous Events
Cite Us!