PTPRZ dephosphorylates ligand-bound ALK dimers

Stable Identifier
R-HSA-9700200
Type
Reaction
Species
Homo sapiens
Compartment
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ALK is dephosphorylated by PTPRZ leading to loss of activity (Perez-Pinera et al, 2007).
Some studies suggest that, rather than being canonically activated by direct binding of PTN and MDK, ALK is activated in a ligand-independent manner by the binding of these ligands to PTPRZ (and possibly PTPRB) instead. PTN- and MDK-binding to PTPRZ/B promotes their oligomerization and catalytic inactivation, thus inhibiting the phosphatase activity and allowing the autoactivation of ALK to predominate (Perez-Pinera et al, 2007; Fukada et al, 2006; Maeda et al, 1999; Kuboyama et al, 2016; reviewed in Deuel, 2013). Discrepancies between these two models remain to be worked out.

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Participates
Catalyst Activity

protein tyrosine phosphatase activity of C4S-PTPRZ1 [plasma membrane]

This event is regulated
Orthologous Events
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