Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ABCG1-mediated transport of intracellular cholesterol to the cell surface
Stable Identifier
R-HSA-266082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
transport vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
HDL remodeling (Homo sapiens)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In an ATP-dependent reaction, ABCG1 mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane. In a tissue culture model system, the active form of ABCG1 is predominantly a tetramer (Vuaghan and Oram 2005). The number of lipid molecules transported per ATP consumed is not known.
Literature References
PubMed ID
Title
Journal
Year
15994327
ABCG1 redistributes cellular cholesterol to domains removable by high density lipoproteins but not by lipid-depleted lipoproteins
Oram, JF
,
Vaughan, AM
J Biol Chem
2005
Participants
Input
ATP [cytosol]
CHOL [transport vesicle membrane]
H2O [cytosol]
Output
ADP [cytosol]
CHOL [plasma membrane]
Pi [cytosol]
Participates
as an event of
HDL remodeling (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
Catalyst Activity
cholesterol transfer activity of ABCG1 dimer [plasma membrane]
Physical Entity
ABCG1 dimer [plasma membrane]
(Homo sapiens)
Activity
cholesterol transfer activity (GO:0120020)
Orthologous Events
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Saccharomyces cerevisiae)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)
Authored
D'Eustachio, P (2008-05-12)
Reviewed
Jassal, B (2008-06-13)
Created
D'Eustachio, P (2008-04-22)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text