I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol

Stable Identifier
R-HSA-1855232
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inositol polyphosphate 1-phosphatase (INPP1) dephosphorylates inositol 1,3,4-trisphosphate (I(1,3,4)P3) to inositol 3,4-bisphosphate (I(3,4)P2) (York et al. 1993).
Literature References
PubMed ID Title Journal Year
8390685 Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase

York, JD, Veile, RA, Donis-Keller, H, Majerus, PW

Proc Natl Acad Sci U S A 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,3,4-trisphosphate 1-phosphatase activity of INPP1:Mg2+ [cytosol]

Physical Entity
INPP1:Mg2+ [cytosol] (Homo sapiens)
Activity
inositol-1,3,4-trisphosphate 1-phosphatase activity (GO:0052829)
Orthologous Events
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Danio rerio)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
Cite Us!