NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

Stable Identifier
R-HSA-2395879
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT18)
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NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP
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NUDT18 (MTH3) catalyzes the reaction of 8-oxo-dGDP and water to form 8-oxo-dGMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.

Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Setoyama, D, Ito, R, Kamiya, H, Yamagata, Y, Sekiguchi, M

J. Biol. Chem. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
8-oxo-dGDP phosphatase activity of NUDT18-1 [cytosol]
Physical Entity
NUDT18-1 [cytosol]
Activity
8-oxo-dGDP phosphatase activity (0044715)
Orthologous Events
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-07-06)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-07-03)