NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

Stable Identifier
R-HSA-2395879
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT18)
Locations in the PathwayBrowser
General
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NUDT18 (MTH3) catalyzes the reaction of 8-oxo-dGDP and water to form 8-oxo-dGMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.

Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Setoyama, D, Ito, R, Kamiya, H, Yamagata, Y, Sekiguchi, M

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
8-oxo-dGDP phosphatase activity of NUDT18-1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created