Reactome | NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

Stable Identifier

R-HSA-2395879

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT18)

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NUDT18 (MTH3) catalyzes the reaction of 8-oxo-dGDP and water to form 8-oxo-dGMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.

Literature References

PubMed ID	Title	Journal	Year
22556419	Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2 Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H	J. Biol. Chem.	2012