Reactome | GSS:Mg2+ dimer synthesizes GSH

GSS:Mg2+ dimer synthesizes GSH

Stable Identifier

R-HSA-174394

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

gamma-glutamylcysteine combines with glycine to form glutathione

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the second step in the formation of glutathione, gamma-glutamylcysteine (gGluCys) ligates with glycine (Gly) to form glutathione (GSH) (Gali & Board 1995). This reaction is catalysed by glutathione synthetase (GSS), a homodimeric enzyme present in the cytosol which requires one Mg2+ cofactor per subunit for activity (Polekhina et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
7646467	Sequencing and expression of a cDNA for human glutathione synthetase Gali, RR, Board, PG	Biochem J	1995
10369661	Molecular basis of glutathione synthetase deficiency and a rare gene permutation event Board, PG, Parker, MW, Gali, RR, Rossjohn, J, Polekhina, G	EMBO J.	1999