GSS:Mg2+ dimer synthesizes GSH

Stable Identifier
R-HSA-174394
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
gamma-glutamylcysteine combines with glycine to form glutathione
Locations in the PathwayBrowser
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In the second step in the formation of glutathione, gamma-glutamylcysteine (gGluCys) ligates with glycine (Gly) to form glutathione (GSH) (Gali & Board 1995). This reaction is catalysed by glutathione synthetase (GSS), a homodimeric enzyme present in the cytosol which requires one Mg2+ cofactor per subunit for activity (Polekhina et al. 1999).

Literature References
PubMed ID Title Journal Year
10369661 Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

Polekhina, G, Board, PG, Gali, RR, Rossjohn, J, Parker, MW

EMBO J. 1999
7646467 Sequencing and expression of a cDNA for human glutathione synthetase

Gali, RR, Board, PG

Biochem J 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione synthase activity of GSS:Mg2+ dimer [cytosol]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Cross References
Rhea
Reviewed
Created