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Dephosphorylation of AKT by PP2A
Stable Identifier
R-HSA-390329
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
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Upon engagement of CTLA4 by B7 molecules, PP2A dissociates from CTLA4 in a phosphorylation-dependent manner. Once released, PP2A acts downstream of early TCR and CD28 signaling by inhibiting the PKB/Akt pathway, leading to the suppression of T cell activation and proliferation. This mechanism highlights PP2A's role in modulating key signaling pathways to maintain immune homeostasis (Parry et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
19405949
Structure-Function analysis of the CTLA-4 interaction with PP2A
Madrenas, J
,
Chau, TA
,
Teft, WA
BMC Immunol
2009
Participants
Input
H2O [cytosol]
p-T,p-S-AKT [cytosol]
(Homo sapiens)
Output
AKT [cytosol]
(Homo sapiens)
Pi [cytosol]
Participates
as an event of
Co-inhibition by CTLA4 (Homo sapiens)
Catalyst Activity
phosphatidate phosphatase activity of PP2A [cytosol]
Physical Entity
PP2A [cytosol]
(Homo sapiens)
Activity
phosphatidate phosphatase activity (GO:0008195)
Orthologous Events
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Mus musculus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
Authored
Garapati, P V (2008-12-16)
Reviewed
Bluestone, JA (2009-06-01)
Esensten, J (2009-06-01)
Created
Garapati, P V (2009-01-26)
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