Dephosphorylation of AKT by PP2A

Stable Identifier
R-HSA-390329
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Upon engagement of CTLA4 by B7 molecules, PP2A dissociates from CTLA4 in a phosphorylation-dependent manner. Once released, PP2A acts downstream of early TCR and CD28 signaling by inhibiting the PKB/Akt pathway, leading to the suppression of T cell activation and proliferation. This mechanism highlights PP2A's role in modulating key signaling pathways to maintain immune homeostasis (Parry et al. 2005).
Literature References
PubMed ID Title Journal Year
19405949 Structure-Function analysis of the CTLA-4 interaction with PP2A

Madrenas, J, Chau, TA, Teft, WA

BMC Immunol 2009
Participants
Participates
Catalyst Activity

phosphatidate phosphatase activity of PP2A [cytosol]

Orthologous Events
Authored
Reviewed
Created
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