Dephosphorylation of AKT by PP2A

Stable Identifier
R-HSA-390329
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Dephosphorylation of AKT by PP2A
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When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.

Literature References
PubMed ID Title Journal Year
19405949 Structure-Function analysis of the CTLA-4 interaction with PP2A

Madrenas, J, Chau, TA, Teft, WA

BMC Immunol 2009
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Output
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as an event of
Catalyst Activity

phosphatidate phosphatase activity of PP2A [cytosol]

Physical Entity
PP2A [cytosol] (Homo sapiens)
Activity
phosphatidate phosphatase activity (GO:0008195)
Orthologous Events
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Canis familiaris)
Dephosphorylation of AKT by PP2A (Danio rerio)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Mus musculus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-26)
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