When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.
Madrenas, J, Chau, TA, Teft, WA
phosphatidate phosphatase activity of PP2A [cytosol]
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