Reactome | LTC4 is exported from the cytosol by ABCC1

LTC4 is exported from the cytosol by ABCC1

Stable Identifier

R-HSA-266070

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate, ABCC1 mediates LTC4 export from the cell

ReviewStatus

5/5

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LTC4 is exported from the cytosol by ABCC1

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On formation, leukotriene C4 (LTC4) is exported to the extracellular region by the ABCC1 transporter (Sjolinder et al. 1999, Leier et al. 1994, Lam et al. 1989) and processed further by cleavage reactions.

Literature References

PubMed ID	Title	Journal	Year
2753893	The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils Soberman, RJ, Owen WF, Jr, Lam, BK, Austen, KF	J Biol Chem	1989
10064732	Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1 Hydman, J, Sjölinder, M, Tornhamre, S, Claesson, HE, Lindgren, J	J Lipid Res	1999