Inositol monophosphatase 1 (IMPA1) and 2 (IMPA2) homodimers dephosphorylate inositol 1-phosphate (I1P) to inositol (Ins). In vitro, IMPA1 and 2 differ in their pH optima and IMPA1 has a significantly greater activity on IP4 than does IMPA2 (McAllister et al. 1992, Ohnishi et al. 2007).
Atack, JR, McAllister, G, Knowles, MR, Maigetter, R, Ragan, CI, Whiting, P, Hammond, EA, Bailey, FJ
Seo, KC, Sato, Y, Ohba, H, Ohnishi, T, Chung, SK, Furuichi, T, Im, J, Yoshikawa, T, Iwayama, Y
inositol monophosphate 1-phosphatase activity of IMPA1/2 [cytosol]
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