RHOBTB3 hydrolyzes ATP

Stable Identifier
R-HSA-9706399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The GTPase domain of RHOBTB3 is considerably divergent and binds and hydrolyzes ATP instead of GTP by virtue of some critical amino acid replacements in the G4 and G5 motifs (Espinosa et al. 2009). Binding of Rab9 increases the ATPase activity (Espinosa et al. 2009).

Literature References
PubMed ID Title Journal Year
19490898 RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport

Espinosa, EJ, Calero, M, Sridevi, K, Pfeffer, SR

Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase activity of RHOBTB3:ATP [trans-Golgi network membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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