The GTPase domain of RHOBTB3 is considerably divergent and binds and hydrolyzes ATP instead of GTP by virtue of some critical amino acid replacements in the G4 and G5 motifs (Espinosa et al. 2009). Binding of Rab9 increases the ATPase activity (Espinosa et al. 2009).
Espinosa, EJ, Calero, M, Sridevi, K, Pfeffer, SR
ATP hydrolysis activity of RHOBTB3:ATP [trans-Golgi network membrane]
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