RHOBTB3 hydrolyzes ATP

Stable Identifier
R-HSA-9706399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
trans-Golgi network membrane, cytosol
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RHOBTB3 hydrolyzes ATP
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The GTPase domain of RHOBTB3 is considerably divergent and binds and hydrolyzes ATP instead of GTP by virtue of some critical amino acid replacements in the G4 and G5 motifs (Espinosa et al. 2009). Binding of Rab9 increases the ATPase activity (Espinosa et al. 2009).

Literature References
PubMed ID Title Journal Year
19490898 RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport

Espinosa, EJ, Calero, M, Sridevi, K, Pfeffer, SR

Cell 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ATPase activity of RHOBTB3:ATP [trans-Golgi network membrane]
Physical Entity
RHOBTB3:ATP [trans-Golgi network membrane]
Activity
ATPase activity (0016887)
Orthologous Events
RHOBTB3 hydrolyzes ATP (Bos taurus)
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
RHOBTB3 hydrolyzes ATP (Danio rerio)
RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)
RHOBTB3 hydrolyzes ATP (Gallus gallus)
RHOBTB3 hydrolyzes ATP (Mus musculus)
RHOBTB3 hydrolyzes ATP (Rattus norvegicus)
RHOBTB3 hydrolyzes ATP (Saccharomyces cerevisiae)
RHOBTB3 hydrolyzes ATP (Schizosaccharomyces pombe)
RHOBTB3 hydrolyzes ATP (Sus scrofa)
RHOBTB3 hydrolyzes ATP (Xenopus tropicalis)
Authored
Rivero Crespo, F  (2020-10-13)
Created
Orlic-Milacic, M  (2020-11-04)
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