Dephosphorylation of JAKs by PTPs

Stable Identifier
R-HSA-877308
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of JAKs by PTPs
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Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2.
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPs-SHP1/2/PTP1B [cytosol]

Physical Entity
PTPs-SHP1/2/PTP1B [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Inferred From
Dephosphorylation of Jaks by Ptps (Mus musculus)
Authored
Garapati, P V  (2010-06-08)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-06-11)
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