Dephosphorylation of JAKs by PTPs

Stable Identifier
R-HSA-877308
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2.

Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of PTPs-SHP1/2/PTP1B [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!