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ATP7A transfers Cu from ATOX1 to SOD3
Stable Identifier
R-HSA-3697838
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi lumen
,
cytosol
,
trans-Golgi network membrane
ReviewStatus
5/5
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Detoxification of Reactive Oxygen Species (Homo sapiens)
ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As inferred from mouse, ATP7A (Menke's ATPase, MNK) transports copper from ATOX in the cytosol to SOD3 in the lumen of the trans golgi network. ATP7A and SOD3 directly interact. Mutations in ATP7A cause Menke's disease, a neurodegenerative condition.
Participants
Input
x 4
ATOX1:Cu1+ [cytosol]
(Homo sapiens)
x 4
ATP [cytosol]
x 4
H2O [cytosol]
x 4
SOD3 [Golgi lumen]
(Homo sapiens)
x 4
Zn2+ [Golgi lumen]
Output
x 4
ADP [cytosol]
x 4
ATOX1 [cytosol]
(Homo sapiens)
x 4
Pi [cytosol]
SOD3 tetramer [Golgi lumen]
(Homo sapiens)
Participates
as an event of
Detoxification of Reactive Oxygen Species (Homo sapiens)
Catalyst Activity
P-type divalent copper transporter activity of ATP7A [trans-Golgi network membrane]
Physical Entity
ATP7A [trans-Golgi network membrane]
(Homo sapiens)
Activity
P-type divalent copper transporter activity (GO:0043682)
Inferred From
Atp7a transfers Cu from Atox1 to Sod3 (Mus musculus)
Authored
May, B (2013-06-09)
Reviewed
Kavdia, M (2013-11-01)
Created
May, B (2013-06-09)
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