PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).
Grindlay, GJ, Dhillon, AS, Kolch, W, Pitt, A, von Kriegsheim, A
Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A
protein serine/threonine phosphatase activity of PPP5C [cytosol]
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