Reactome | PP5 dephosphorylates RAF1 S338

PP5 dephosphorylates RAF1 S338

Stable Identifier

R-HSA-5675433

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

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PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
21779496	Raf family kinases: old dogs have learned new tricks Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W	Genes Cancer	2011
16892053	Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5 von Kriegsheim, A, Pitt, A, Grindlay, GJ, Kolch, W, Dhillon, AS	Nat. Cell Biol.	2006