PTP1B dephosphorylates JAK2

Stable Identifier
R-HSA-1169210
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PTP1B dephosphorylates JAK2
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PTP1B dephosphorylates JAK2 (Gu et al. 2003), limiting ligand-dependent signaling.
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]

Physical Entity
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Inferred From
Ptp1b dephosphorylates Jak2 (Mus musculus)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-13)
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