5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

Stable Identifier
R-HSA-73814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
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The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).

Literature References
Participants
Participates
Catalyst Activity

phosphoribosylamine-glycine ligase activity of GART [cytosol]

Orthologous Events
Authored
Created
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