Reactome | SLC7A4 exchanges G6P for Pi across the ER membrane

SLC7A4 exchanges G6P for Pi across the ER membrane

Stable Identifier

R-HSA-198513

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, endoplasmic reticulum lumen

Synonyms

alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)

ReviewStatus

5/5

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SLC7A4 exchanges G6P for Pi across the ER membrane

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The SLC37A4 transport protein in the endoplasmic reticulum membrane mediates the exchange of cytosolic G6P (glucose-6-phosphate) and Pi (orthophosphate) from the endoplasmic reticulum lumen. Defects in this transporter are associated with glycogen storage disease type Ib (Gerin et al. 1997; Chen et al. 2008; Veiga-da-Cunha et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9428641	Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib Collet, JF, Achouri, Y, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E	FEBS Lett	1997
18337460	The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic Chou, JY, Pan, CJ, Mansfield, BC, Nandigama, K, Ambudkar, SV, Chen, SY	FASEB J.	2008
9758626	A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic Fenske, CD, Chen, Y-T, Leonard, JV, Schweitzer, S, de Barsy, T, Maire, I, Lee, PJ, de Lonlay, P, Vikkula, M, McConkie-Rosell, A, Gerin, I, Dionisi-Vici, C, Veiga-da-Cunha, M, Van Schaftingen, E	Am. J. Hum. Genet.	1998