Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin

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R-HSA-8955869
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Reaction [transition]
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Homo sapiens
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Polyglutamylase complex polyglutamylates alpha subunits of tubulin. The complex contains TTLL1 (Tubulin tyrosine ligase-like 1) protein. The human complex has not been characterized experimentally. Its organization and function have been inferred from biochemical and genetic studies of its mouse counterpart. The mouse complex has been isolated and four additional protein components have been identified (Janke et al. 2005). A mouse mutation that disrupts one of these, Tpgs1, is associated with failure of polyglytamylation of alpha-chains in microtubules (Ikegami et al. 2007). In this event polyglutamylation is arbitrarily shown on only one tubulin protofilament within the microtubule.

Literature References
PubMed ID Title Journal Year
17360631 Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function

Ikegami, K, Heier, RL, Taruishi, M, Takagi, H, Mukai, M, Shimma, S, Taira, S, Hatanaka, K, Morone, N, Yao, I, Campbell, PK, Yuasa, S, Janke, C, Macgregor, GR, Setou, M

Proc. Natl. Acad. Sci. U.S.A. 2007
15890843 Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Janke, C, Rogowski, K, Wloga, D, Regnard, C, Kajava, AV, Strub, JM, Temurak, N, van Dijk, J, Boucher, D, van Dorsselaer, A, Suryavanshi, S, Gaertig, J, Eddé, B

Science 2005
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Title
tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol]
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