Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin

Stable Identifier
Reaction [transition]
Homo sapiens
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Polyglutamylase complex polyglutamylates alpha subunits of tubulin in the brain. The complex contains TTLL1 (Tubulin tyrosine ligase-like 1) protein. The human complex has not been characterized experimentally. Its organization and function have been inferred from biochemical and genetic studies of its mouse counterpart. The mouse complex has been isolated and four additional protein components have been identified (Janke et al. 2005). A mouse mutation that disrupts one of these, Tpgs1, is associated with failure of polyglytamylation of alpha-chains in microtubules (Ikegami et al. 2007). In this event polyglutamylation is arbitrarily shown on only one tubulin protofilament within the microtubule.
Literature References
PubMed ID Title Journal Year
15890843 Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Gaertig, J, Eddé, B, Strub, JM, Boucher, D, Temurak, N, Suryavanshi, S, Rogowski, K, van Dijk, J, Regnard, C, Wloga, D, Kajava, AV, van Dorsselaer, A, Janke, C

Science 2005
17360631 Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function

Mukai, M, Takagi, H, Setou, M, Hatanaka, K, Campbell, PK, Ikegami, K, Yao, I, Morone, N, Shimma, S, Taira, S, Taruishi, M, Macgregor, GR, Heier, RL, Yuasa, S, Janke, C

Proc. Natl. Acad. Sci. U.S.A. 2007
Event Information
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Catalyst Activity

tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol]

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