Sustained activation of SRC kinase by SHP2

Stable Identifier
R-HSA-177923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Sustained activation of SRC kinase by SHP2
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SHP2 can dephosphorylate paxillin, which leads to Csk dissociation from the paxillin-Src complex and Src activation. Src is an SHP2 effector in EGF-stimulated Erk activation and cell migration.

Literature References
PubMed ID Title Journal Year
15574420 A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

Montagner, A, Yart, A, Dance, M, Perret, B, Salles, JP, Raynal, P

J Biol Chem 2005
14665621 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Ren, Y, Meng, S, Mei, L, Zhao, ZJ, Jove, R, Wu, J

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Activity
non-membrane spanning protein tyrosine phosphatase activity (0004726)
Orthologous Events
Sustained activation of SRC kinase by SHP2 (Bos taurus)
Sustained activation of SRC kinase by SHP2 (Caenorhabditis elegans)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Danio rerio)
Sustained activation of SRC kinase by SHP2 (Mus musculus)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)