Sustained activation of SRC kinase by SHP2

Stable Identifier
R-HSA-177923
Type
Reaction
Species
Homo sapiens
Compartment
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SHP2 can dephosphorylate paxillin, which leads to Csk dissociation from the paxillin-Src complex and Src activation. Src is an SHP2 effector in EGF-stimulated Erk activation and cell migration.

Literature References
PubMed ID Title Journal Year
14665621 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Meng, S, Mei, L, Zhao, ZJ, Ren, Y, Wu, J, Jove, R

J Biol Chem 2004
15574420 A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

Salles, JP, Raynal, P, Dance, M, Yart, A, Perret, B, Montagner, A

J Biol Chem 2005
Participants
Participates
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

Orthologous Events
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