Sustained activation of SRC kinase by SHP2

Stable Identifier
R-HSA-177923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Sustained activation of SRC kinase by SHP2
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SHP2 can dephosphorylate paxillin, which leads to CSK dissociation from the paxillin-SRC complex and SRC activation. SRC is an SHP2 effector in EGF-stimulated ERK activation and cell migration.
Literature References
PubMed ID Title Journal Year
14665621 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Meng, S, Mei, L, Zhao, ZJ, Ren, Y, Wu, J, Jove, R

J Biol Chem 2004
15574420 A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

Salles, JP, Raynal, P, Dance, M, Yart, A, Perret, B, Montagner, A

J Biol Chem 2005
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Output
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as an event of
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Orthologous Events
Sustained activation of SRC kinase by SHP2 (Bos taurus)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Mus musculus)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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