SHP2 can dephosphorylate paxillin, which leads to Csk dissociation from the paxillin-Src complex and Src activation. Src is an SHP2 effector in EGF-stimulated Erk activation and cell migration.
Meng, S, Mei, L, Zhao, ZJ, Ren, Y, Wu, J, Jove, R
Salles, JP, Raynal, P, Dance, M, Yart, A, Perret, B, Montagner, A
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
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