Sustained activation of SRC kinase by SHP2

Stable Identifier
R-HSA-177923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sustained activation of SRC kinase by SHP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SHP2 can dephosphorylate paxillin, which leads to Csk dissociation from the paxillin-Src complex and Src activation. Src is an SHP2 effector in EGF-stimulated Erk activation and cell migration.

Literature References
PubMed ID Title Journal Year
15574420 A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

Montagner, A, Yart, A, Dance, M, Perret, B, Salles, JP, Raynal, P

J Biol Chem 2005
14665621 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Ren, Y, Meng, S, Mei, L, Zhao, ZJ, Jove, R, Wu, J

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Activity
non-membrane spanning protein tyrosine phosphatase activity (0004726)
Orthologous Events
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Danio rerio)
Sustained activation of SRC kinase by SHP2 (Mus musculus)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
Cite Us!