Sustained activation of SRC kinase by SHP2

Stable Identifier
R-HSA-177923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SHP2 can dephosphorylate paxillin, which leads to Csk dissociation from the paxillin-Src complex and Src activation. Src is an SHP2 effector in EGF-stimulated Erk activation and cell migration.

Literature References
PubMed ID Title Journal Year
15574420 A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

Montagner, A, Yart, A, Dance, M, Perret, B, Salles, JP, Raynal, P

J Biol Chem 2005
14665621 Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

Ren, Y, Meng, S, Mei, L, Zhao, ZJ, Jove, R, Wu, J

J Biol Chem 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created