ACLY tetramer transforms CIT to Ac-CoA

Stable Identifier
R-HSA-75848
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Generation of Cytoplasmic Acetyl CoA from Citrate
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While fatty acid synthesis from acetyl CoA (Ac-CoA) proceeds in the cytosol, most Ac-CoA in the cell is generated within the mitochondria, by oxidative decarboxylation of the pyruvate derived from glycolysis, as well as from a number of reactions of amino acid catabolism. Mitochondrial Ac-CoA is transported to the cytosol as citrate (CIT) to participate in fatty acid biosynthesis. Cytosolic ATP-citrate synthase (ACLY), in tetrameric form, catalyses the transformation of CIT to Ac-CoA and and plays an essential role in lipogenesis, adipogenesis and differentiation of 3T3-L1 preadipocytic cells (Elshourbagy et al. 1992, Lin et al. 2013). Cytosolic MORC family CW-type zinc finger protein 2 (MORC2) positively regulates the activity of ACLY, thus could be a mediator of lipogenesis, adipogenic differentiation, and lipid homeostasis (Sanchez-Solana et al. 2014).

Literature References
PubMed ID Title Journal Year
23932781 Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Lin, R, Tao, R, Gao, X, Li, T, Zhou, X, Guan, KL, Xiong, Y, Lei, QY

Mol. Cell 2013
24286864 Cytosolic functions of MORC2 in lipogenesis and adipogenesis

Sánchez-Solana, B, Li, DQ, Kumar, R

Biochim. Biophys. Acta 2014
1371749 Cloning and expression of a human ATP-citrate lyase cDNA

Elshourbagy, NA, Near, JC, Kmetz, PJ, Wells, TN, Groot, PH, Saxty, BA, Hughes, SA, Franklin, M, Gloger, IS

Eur J Biochem 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATP citrate synthase activity of ACLY tetramer [cytosol]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Cross References
Rhea
Authored
Created
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