ACLY tetramer transforms CIT to Ac-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
Generation of Cytoplasmic Acetyl CoA from Citrate
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While fatty acid synthesis from acetyl CoA (Ac-CoA) proceeds in the cytosol, most Ac-CoA in the cell is generated within the mitochondria, by oxidative decarboxylation of the pyruvate derived from glycolysis, as well as from a number of reactions of amino acid catabolism. Mitochondrial Ac-CoA is transported to the cytosol as citrate (CIT) to participate in fatty acid biosynthesis. Cytosolic ATP-citrate synthase (ACLY), in tetrameric form, catalyses the transformation of CIT to Ac-CoA and and plays an essential role in lipogenesis, adipogenesis and differentiation of 3T3-L1 preadipocytic cells (Elshourbagy et al. 1992, Lin et al. 2013). Cytosolic MORC family CW-type zinc finger protein 2 (MORC2) positively regulates the activity of ACLY, thus could be a mediator of lipogenesis, adipogenic differentiation, and lipid homeostasis (Sanchez-Solana et al. 2014).

Literature References
PubMed ID Title Journal Year
24286864 Cytosolic functions of MORC2 in lipogenesis and adipogenesis

Kumar, R, Sánchez-Solana, B, Li, DQ

Biochim. Biophys. Acta 2014
23932781 Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Xiong, Y, Guan, KL, Zhou, X, Gao, X, Lei, QY, Lin, R, Li, T, Tao, R

Mol. Cell 2013
1371749 Cloning and expression of a human ATP-citrate lyase cDNA

Gloger, IS, Elshourbagy, NA, Wells, TN, Franklin, M, Saxty, BA, Hughes, SA, Groot, PH, Kmetz, PJ, Near, JC

Eur J Biochem 1992
Catalyst Activity

ATP citrate synthase activity of ACLY tetramer [cytosol]

This event is regulated
Positively by
Orthologous Events
Cross References
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