SHP2 dephosphorylates Tyr 992 on EGFR

Stable Identifier
R-HSA-177935
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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SHP2 dephosphorylates Tyr 992 on EGFR
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The tyrosine-protein phosphatase SHP2 is a positive effector of EGFR signalling. SHP2 inhibits the tyrosine-dependent translocation of RasGAP (catalyses Ras inactivation) to the plasma membrane, thereby keeping it away from Ras-GTP (its substrate). This inhibition is achieved by the dephosphorylation of a RasGAP binding site on the EGF receptor.

Literature References
PubMed ID Title Journal Year
14560030 Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling

Agazie, YM, Hayman, MJ

Mol Cell Biol 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Activity
non-membrane spanning protein tyrosine phosphatase activity (0004726)
Orthologous Events
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
SHP2 dephosphorylates Tyr 992 on EGFR (Caenorhabditis elegans)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Danio rerio)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)