SHP2 dephosphorylates Tyr 992 on EGFR

Stable Identifier
R-HSA-177935
Type
Reaction
Species
Homo sapiens
Compartment
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The tyrosine-protein phosphatase SHP2 is a positive effector of EGFR signalling. SHP2 inhibits the tyrosine-dependent translocation of RasGAP (catalyses Ras inactivation) to the plasma membrane, thereby keeping it away from Ras-GTP (its substrate). This inhibition is achieved by the dephosphorylation of a RasGAP binding site on the EGF receptor.

Literature References
PubMed ID Title Journal Year
14560030 Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling

Agazie, YM, Hayman, MJ

Mol Cell Biol 2003
Participants
Participates
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

Orthologous Events
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