Reactome | PRPS1 dimer pyrophosphorylates R5P using dATP

PRPS1 dimer pyrophosphorylates R5P using dATP

Stable Identifier

R-HSA-111215

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate

ReviewStatus

5/5

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PRPS1 dimer pyrophosphorylates R5P using dATP

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Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyzes the reaction of D-ribose 5-phosphate and dATP to form 5-phospho-alpha-D-ribose 1-diphosphate and 2'-deoxyadenosine 5'-monophosphate. While phosphoribosyl pyrophosphate synthetase 1 works well with either ATP or dATP as a substrate in vitro, the extent of the dATP reaction in vivo is unclear, as cellular dATP concentrations are normally very low (Fox and Kelley 1971; reviewed in Hove-Jensen et al., 2016).

Literature References

PubMed ID	Title	Journal	Year
4328836	Human phosphoribosylpyrophosphate synthetase Fox, IH, Kelley, WN	J Biol Chem	1971
28031352	Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance Hove-Jensen, B, Andersen, KR, Kilstrup, M, Martinussen, J, Switzer, RL, Willemoës, M	Microbiol Mol Biol Rev	2017