Type I Na+-coupled phosphate co-transport

Stable Identifier
R-HSA-428609
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Four SLC17 genes are thought to encode type I Na+-dependent phosphate co-transporters in humans. SLC17A1 (NPT1) encodes Na+-dependent phosphate co-transporter 1 (Na/Pi-4). It is abundant in human kidney cortex, liver and brain and is important for the resorption of phosphate by the kidney. It does this by actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (Chong SS et al, 1993).

Three close relatives of NPT1 have been identified through genomic analysis and designated NPT3 (SLC17A2), NPT4 (SLC17A3) and a putative small intestine sodium-dependent phosphate co-transporter (SLC17A4). None of these three proteins have been functionally characterized yet.

Literature References
PubMed ID Title Journal Year
8288239 Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23

Chong, SS, Kristjansson, K, Zoghbi, HY, Hughes, MR

Genomics 1993
Participants
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Catalyst Activity
Title
sodium:phosphate symporter activity of SLC17A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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