DRheb is inhibited by the TSC1/2 complex

Stable Identifier
R-DME-110491
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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DRheb is inhibited by the TSC1/2 complex
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The DTSC1/2 complex antagonizes the amino-acid-TOR signaling pathway. DTSC1/2 complex has a GTPase-activating protein domain (GAP). DRheb (a small GTPase called Ras homologue enriched in brain) is a target for DTSC2 GAP activity. As DRheb is a downstream effector from DTSC1/2, its inhibition by DTSC1/2 results in growth inhibition.
Literature References
PubMed ID Title Journal Year
12771962 Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.

Zhang, Y, Gao, X, Saucedo, LJ, Ru, B, Edgar, BA, Pan, D

Nat Cell Biol 2003
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of cell growth (0030308)
Catalyst Activity

GTPase activator activity of DTSC1:DTSC2 complex [cytosol]

Physical Entity
DTSC1:DTSC2 complex [cytosol] (Drosophila melanogaster)
Activity
GTPase activator activity (GO:0005096)
Authored
Jassal, B  (2004-02-11)
Created
Jassal, B  (2004-02-11)
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