Reactome | PRPS dimers pyrophosphorylate R5P using ATP

PRPS dimers pyrophosphorylate R5P using ATP

Stable Identifier

R-HSA-73580

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)

ReviewStatus

5/5

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PRPS dimers pyrophosphorylate R5P using ATP

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Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971; reviewed in Hove-Jensen et al., 2016). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

Literature References

PubMed ID	Title	Journal	Year
4328836	Human phosphoribosylpyrophosphate synthetase Fox, IH, Kelley, WN	J Biol Chem	1971
28031352	Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance Hove-Jensen, B, Andersen, KR, Kilstrup, M, Martinussen, J, Switzer, RL, Willemoës, M	Microbiol Mol Biol Rev	2017