D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate

Stable Identifier
R-HSA-73580
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
Locations in the PathwayBrowser
General
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Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

Literature References
PubMed ID Title Journal Year
4328836 Human phosphoribosylpyrophosphate synthetase

Fox, IH, Kelley, WN

J Biol Chem 1971
Participants
Participates
Catalyst Activity

ribose phosphate diphosphokinase activity of PRPS2 dimer, PRPS1L dimer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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