MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier
R-HSA-6801342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) catalyses the irreversible transformation of 5-formyltetrahydrofolate (5-formyl-THF) to 5,10-methenyltetrahydrofolate (5,10-methenyl-THF) (Dayan et al. 1995). MTHFS has higher affinity for the polyglutamate form of 5-formyl-THF (5-formyl-THFPG) (Bertrand et al. 1987). This reaction of tetrahydrofolate metabolism helps regulate carbon flow through the folate-dependent one-carbon metabolic network which is essential for growth and proliferation of cells.

Literature References
PubMed ID Title Journal Year
3801490 Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates

Bertrand, R, MacKenzie, RE, Jolivet, J

Biochim. Biophys. Acta 1987
8522195 Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA

Dayan, A, Bertrand, R, Beauchemin, M, Chahla, D, Mamo, A, Filion, M, Skup, D, Massie, B, Jolivet, J

Gene 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
5-formyltetrahydrofolate cyclo-ligase activity of MTHFS [cytosol]
Physical Entity
Activity
Orthologous Events
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