PGP:Mg2+ dimer hydrolyses G3P to glycerol

Stable Identifier
R-HSA-8955794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
sn-glycerol 3-phosphate + H2O => glycerol + phosphate
ReviewStatus
5/5
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Cytosolic PGP (Glycerol-3-phosphate phosphatase) catalyzes the hydrolysis of G3P (glycerol 3-phosphate) to glycerol and phosphate. This reaction is inferred from the properties of the human enzyme overexpressed in mouse cells (Mugabo et al. 2016). The enzyme is inferred to function as a homodimer with one Mg++ ion bound to each subunit, from the properties of the mouse enzyme (Seifried et al. 2014). Al-Maas et al. (2022a,b) hypothesize that PGP, by dissipating glucose-derived glycerol in the liver and pancreas, may play a role in minimizing the effects of hyperglycemia. In the male gonad, PGP activity may be required for normal spermatogenesis (Oppong et al. 2024).
Literature References
PubMed ID Title Journal Year
35272070 Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress

Lussier, R, Guida, J, Al-Mulla, F, Levens, EJ, Al-Mass, A, Prentki, M, Possik, E, Poursharifi, P, Ahmad, R, Madiraju, SR, Mugabo, Y, Peyot, ML, Sladek, R

Mol Metab 2022
24338473 Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities

Schindelin, H, Seifried, A, Gohla, A, Manhard, J, Duraphe, PS, Segerer, G, Schultz, J, Knobloch, G

J Biol Chem 2014
39542419 Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice

Oppong, A, Ghosh, A, Al-Mulla, F, Morales, C, Clarke, HJ, O'Flaherty, C, Paquet, M, Prentki, M, Leung, YH, Boerboom, D, Madiraju, SR, Peyot, ML, Boyer, A

Mol Metab 2024
36198384 Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia

Lussier, R, Oppong, A, Ghosh, A, Al-Mulla, F, Al-Mass, A, Prentki, M, Possik, E, Poursharifi, P, Leung, YH, Ahmad, R, Madiraju, SR, Mugabo, Y, Chenier, I, Peyot, ML, Sladek, R

Mol Metab 2022
26755581 Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

Gezzar, S, Zhang, D, Lamontagne, J, Al-Mass, A, Zhao, S, Iglesias, J, Seifried, A, Gohla, A, Attane, C, Joly, E, Prentki, M, Poursharifi, P, Madiraju, SR, Mugabo, Y, Peyot, ML

Proc. Natl. Acad. Sci. U.S.A. 2016
Participants
Participates
Event Information
Catalyst Activity

glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
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