PGP:Mg2+ dimer hydrolyses 3PG to glycerol

Stable Identifier
R-HSA-8955794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PGP:Mg2+ dimer hydrolyses 3PG to glycerol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycerol-3-phosphate (aka 3-phospho-D-glycerate, 3PG) is a metabolic intermediate of glucose, lipid and energy metabolism. Its cellular levels may be regulated by cytosolic glycerol-3-phosphate phosphatase (PGP aka G3PP), which hydrolyses 3PG to glycerol. PGP functions as a homodimer, binding one Mg2+ ion per subunit. The function of the human protein is inferred from rat Pgp characterisation and functional studies (Mugabo et al. 2016).

Literature References
PubMed ID Title Journal Year
26755581 Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

Mugabo, Y, Zhao, S, Seifried, A, Gezzar, S, Al-Mass, A, Zhang, D, Lamontagne, J, Attane, C, Poursharifi, P, Iglesias, J, Joly, E, Peyot, ML, Gohla, A, Madiraju, SR, Prentki, M

Proc. Natl. Acad. Sci. U.S.A. 2016
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
glycerol biosynthetic process (0006114)
Catalyst Activity
Catalyst Activity
Title
glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol]
Physical Entity
PGP:Mg2+ dimer [cytosol]
Activity
glycerol-3-phosphatase activity (0043136)
Inferred From
Pgp:Mg2+ dimer hydrolyses 3PG to glycerol (Rattus norvegicus)
Authored
Jassal, B  (2017-01-13)
Reviewed
D'Eustachio, P  (2017-01-30)
Created
Jassal, B  (2017-01-13)