PGP:Mg2+ dimer hydrolyses 3PG to glycerol

Stable Identifier
R-HSA-8955794
Type
Reaction
Species
Homo sapiens
Compartment
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Glycerol-3-phosphate (aka 3-phospho-D-glycerate, 3PG) is a metabolic intermediate of glucose, lipid and energy metabolism. Its cellular levels may be regulated by cytosolic glycerol-3-phosphate phosphatase (PGP aka G3PP), which hydrolyses 3PG to glycerol. PGP functions as a homodimer, binding one Mg2+ ion per subunit. The function of the human protein is inferred from rat Pgp characterisation and functional studies (Mugabo et al. 2016).

Literature References
PubMed ID Title Journal Year
26755581 Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

Gezzar, S, Zhang, D, Lamontagne, J, Al-Mass, A, Zhao, S, Iglesias, J, Seifried, A, Gohla, A, Attane, C, Joly, E, Prentki, M, Poursharifi, P, Madiraju, SR, Mugabo, Y, Peyot, ML

Proc. Natl. Acad. Sci. U.S.A. 2016
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Event Information
Catalyst Activity

glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol]

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